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Digitaline Nativelle and Heparin Intravenous, Subcutaneous

Determining the interaction of Digitaline Nativelle and Heparin Intravenous, Subcutaneous and the possibility of their joint administration.

Check result:

Digitaline Nativelle <> Heparin Intravenous, Subcutaneous

Relevance: 11.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data reveal that the free fraction of digoxin is increased in uremic patients following administration of heparin after five minutes of hemodialysis. The mechanism is displacement of digoxin from albumin-binding sites. The resulting increase in digoxin was not associated with toxicity and was clinically insignificant. However, this interaction may be important as stable doses digoxin are established in some patients receiving heparin infusions. More data are needed.

References

van der Vijgh WJ, Oe PL "Pharmacokinetic aspects of digoxin in patients with terminal renal failure III: effect of heparin." Int J Clin Pharmacol Biopharm 15 (1977): 560-2
Storstein L, Janssen H "Studies on digitalis VI: the effect of heparin on serum protein binding of digitoxin and digoxin." Clin Pharmacol Ther 20 (1976): 15-23

Digitaline Nativelle

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digitaline Nativelle?

Heparin Intravenous, Subcutaneous

Generic Name: heparin

Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush

Synonyms: Heparin

What is Heparin Intravenous, Subcutaneous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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