Digitaline Nativelle and Noxafil (Posaconazole Oral Suspension)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Posaconazole may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Theoretically, posaconazole may increase the plasma concentrations and pharmacologic effects of digoxin. Although clinical data are lacking, the interaction has been reported with other azole antifungal agents. Two- to fourfold increases in digoxin concentrations have been reported after initiation of itraconazole. Toxicity has occurred in some cases, most with an onset of 9 to 13 days following the start of azole therapy. The exact mechanism of the interaction is unknown but may be related to azole-induced inhibition of the P-glycoprotein transport of digoxin, resulting in reduced renal clearance.

MANAGEMENT: Caution is advised if digoxin must be used concurrently with posaconazole. Serum digoxin levels should be checked frequently and the dosage adjusted accordingly, particularly following initiation or discontinuation of posaconazole in patients who are stabilized on their digoxin regimen. Patients should be advised to notify their doctor if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

Digitaline Nativelle

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digitaline Nativelle?

Noxafil (Posaconazole Oral Suspension)

Generic Name: posaconazole

Brand name: Noxafil

Synonyms: Noxafil

What is Noxafil (Posaconazole Oral Suspension)?