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Digitaline Nativelle and Parathyroid hormone Subcutaneous

Determining the interaction of Digitaline Nativelle and Parathyroid hormone Subcutaneous and the possibility of their joint administration.

Check result:
Digitaline Nativelle <> Parathyroid hormone Subcutaneous
Relevance: 11.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Parathyroid hormone may alter the effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your heart condition worsens or you experience symptoms of digoxin toxicity such as nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: Parathyroid hormone may alter the effects of digitalis glycosides. The inotropic effects of digitalis glycosides are affected by serum calcium levels. Since parathyroid hormone causes a transient increase in serum calcium, it can potentiate the risk of digitalis toxicity if hypercalcemia develops. On the other hand, digitalis efficacy may be reduced if hypocalcemia occurs. Severe cases of both hypercalcemia and hypocalcemia have been reported during treatment with parathyroid hormone. The risk of hypercalcemia is greatest when starting or increasing the dose of parathyroid hormone, whereas the risk of hypocalcemia is greatest when parathyroid hormone is withheld, missed, or abruptly discontinued.

MANAGEMENT: Serum calcium and digitalis levels should be closely monitored during parathyroid hormone therapy, and the digitalis dosage adjusted as necessary. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

References
  • "Product Information. Natpara (parathyroid hormone)." NPS Pharmaceuticals, Bedminster, NJ.
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Digitaline Nativelle

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

Parathyroid hormone Subcutaneous

Generic Name: parathyroid hormone

Brand name: Natpara

Synonyms: Parathyroid hormone, Parathyroid Hormone

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.