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Digitaline Nativelle and Propafenone

Determining the interaction of Digitaline Nativelle and Propafenone and the possibility of their joint administration.

Check result:
Digitaline Nativelle <> Propafenone
Relevance: 11.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using digoxin together with propafenone may increase the effects of digoxin. Contact your doctor if you experience nausea, vomiting, decreased appetite, diarrhea, confusion, seizures, hallucinations, light "halos" around objects, green or yellow vision, fatigue, irregular heartbeats, and abnormally fast or slow heartbeats. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Propafenone may increase digoxin serum levels. Toxicity may result. The mechanism may be related to changes in the volume of distribution and in the renal and nonrenal clearance of digoxin.

MANAGEMENT: If these drugs must be used together, the patient should be monitored closely for evidence of digoxin toxicity. Patients should be advised to notify their physicians if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

References
  • Zalzstein E, Koren G, Bryson SM, Freedom RM "Interaction between digoxin and propafenone in children." J Pediatr 116 (1990): 310-2
  • Belz GG, Doering W, Munkes R, Matthews J "Interaction between digoxin and calcium antagonists and antiarrhythmic drugs." Clin Pharmacol Ther 33 (1983): 410-7
  • Calvo MV, Martin-Suarez A, Luengo CM, Avila C, Cascon M, Dominguez-Gil Hurle A "Interaction between digoxin and propafenone." Ther Drug Monit 11 (1989): 10-5
  • Nolan PE Jr, Marcus FI, Erstad BL, Hoyer GL, Furman C, Kirsten EB "Effects of coadministration of propafenone on the pharmacokinetics of digoxin in healthy volunteer subjects." J Clin Pharmacol 29 (1989): 46-52
  • Calvo MV, Martin-Suarez A, Luengo CM, et al "Interaction between digoxin and propafenone." Ther Drug Monit 11 (1989): 10-5
  • Bigot MC, Debruyne D, Bonnefoy L, Grollier G, Moulin M, Potier JC "Serum digoxin levels related to plasma propafenone levels during concomitant treatment." J Clin Pharmacol 31 (1991): 521-6
Digitaline Nativelle

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

Propafenone

Generic Name: propafenone

Brand name: Rythmol, Rythmol SR

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction