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Digitaline Nativelle and Rifadin

Determining the interaction of Digitaline Nativelle and Rifadin and the possibility of their joint administration.

Check result:

Digitaline Nativelle <> Rifadin

Relevance: 11.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using digoxin together with rifAMPin. Combining these medications may reduce the blood levels and effects of digoxin. Contact your doctor if your condition changes or you experience a worsening of your heart symptoms. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with rifampin may decrease the plasma concentrations of digoxin. The proposed mechanism is induction of the P-glycoprotein-mediated intestinal efflux and renal tubular secretion of digoxin by rifampin. In 18 healthy volunteers, administration of a single 0.25 mg dose of digoxin following pretreatment with rifampin 300 mg twice a day for 7 days resulted in a 38% decrease in digoxin peak plasma concentration (Cmax) and 25% decrease in systemic exposure (AUC) compared to administration of digoxin alone.

MANAGEMENT: Caution is advised if digoxin is used in combination with rifampin. Digoxin levels should be checked more frequently and the dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of rifampin in patients who are stabilized on their digoxin regimen. Patients should be advised to notify their physician if they experience a worsening of their heart symptoms.

References

Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
Gault H, Longerich L, Dawe RT, Fine A "Digoxin-rifampin interaction." Clin Pharmacol Ther 35 (1984): 750-4
Novi C, Bissoli F, Simonati V, Volpini T, Baroli A, Vignati G "Rifampin and digoxin: possible drug interaction in a dialysis patient." JAMA 244 (1980): 2521-2
Drescher S, Glaeser H, Murdter T, Hitzl M, Eichelbaum M, Fromm MF "P-glycoprotein-mediated intestinal and biliary digoxin transport in humans." Clin Pharmacol Ther 73 (2003): 223-31
Greiner B, Eichelbaum M, Fritz P, et al "The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin." J Clin Invest 104 (1999): 147-53
Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Bussey HI, Merritt GJ, Hill EG "The influence of rifampin on quinidine and digoxin." Arch Intern Med 144 (1984): 1021-3
Baciewicz AM, Self TH, Bekemeyer WB "Update on rifampin drug interactions." Arch Intern Med 147 (1987): 565-8
Gurley BJ, Swain A, Williams DK, Barone G, Battu SK "Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: comparative effects of St. John's wort, Echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics." Mol Nutr Food Res 52 (2008): 772-9
Marcus FI "Pharmacokinetic interactions between digoxin and other drugs." J Am Coll Cardiol 5 (1985): a82-90
Lau AH, Lam NP, Piscitelli SC, et al "Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives." Clin Pharmacokinet 23 (1992): 328-64

Digitaline Nativelle

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digitaline Nativelle?

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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