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Digitek and Prestalia

Determining the interaction of Digitek and Prestalia and the possibility of their joint administration.

Check result:

Digitek <> Prestalia

Relevance: 19.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Perindopril may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Some ACE inhibitors may decrease the renal clearance of digoxin. Increased plasma digoxin levels may result. The proposed mechanism is reduced tubular secretion of digoxin. Some occurrences of decreased digoxin levels also have been reported. Patients with congestive heart failure (CHF) or renal impairment may have a greater risk of developing digoxin toxicity.

MANAGEMENT: While this combination has demonstrated benefits in some CHF patients, their clinical response and digoxin levels should be monitored. Patients should be advised to notify their physician if they experience nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

References

Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
Douste-Blazy P, Blanc M, Montastruc JL, et al "Is there any interaction between digoxin and enalapril?" Br J Clin Pharmacol 22 (1986): 752-3
Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
Miyakawa T, Shionoiri H, Takasaki I, et al "The effect of captopril on pharmacokinetics of digoxin in patients with mild congestive heart failure." J Cardiovasc Pharmacol 17 (1991): 576-80
Kromer EP, Elsner D, Riegger GA "Digoxin, converting-enzyme inhibition (quinapril), and the combination in patients with congestive heart failure functional class II and sinus rhythm." J Cardiovasc Pharmacol 16 (1990): 9-14
Cleland JG, Dargie HJ, Pettigrew A, Gillen G, Robertson JI "The effects of captopril on serum digoxin and urinary urea and digoxin clearances in patients with congestive heart failure." Am Heart J 112 (1986): 130-5
Doering W, Maass L, Irmisch R, Konig E "Pharmacokinetic interaction study with ramipril and digoxin in healthy volunteers." Am J Cardiol 59 (1987): d60-4

Digitek

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digitek (Oral)

What is Digitek?

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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