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Digox and Quinidex Extentabs

Determining the interaction of Digox and Quinidex Extentabs and the possibility of their joint administration.

Check result:

Digox <> Quinidex Extentabs

Relevance: 26.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using digoxin together with quiNIDine. Combining these medications may significantly increase the blood levels and effects of digoxin. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Quinidine significantly increases serum digoxin levels in more than 90% of patients. The proposed mechanism is quinidine inhibition of the P-glycoprotein-mediated intestinal efflux and/or renal tubular secretion of digoxin. Serum digoxin levels may increase 2-fold on average, although the interaction is subject to a high degree of interpatient variability.

MANAGEMENT: Caution is advised if digoxin must be used in combination with quinidine. Empiric reduction in digoxin dosing may be appropriate at the initiation of quinidine therapy. Serum digoxin levels and pharmacologic effects should be closely monitored, and the dosage adjusted accordingly. Patients should be advised to notify their physician if they experience signs of digitalis toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

References

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Digox

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digox (Oral), Digox Tablets

What is Digox?

Quinidex Extentabs

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quinidex Extentabs?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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