Digox and Zolate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Cholecalciferol can increase the levels of calcium in your body. Since calcium can enhance the effects of digoxin on the heart, using too much cholecalciferol can cause digoxin toxicity and irregular heart rhythm. If your doctor prescribes these medications together, you may need a dose adjustment or more frequent blood tests to monitor calcium and digoxin levels. You should use cholecalciferol exactly as directed and avoid large increases in your daily dietary calcium intake while using cholecalciferol. Contact your doctor if you experience symptoms that could indicate high blood calcium, such as weakness, fatigue, headache, drowsiness, dizziness, ringing in the ears, loss of appetite, nausea, vomiting, constipation, dry mouth, a metallic taste in the mouth, bone or muscle pain, incoordination, frequent urination, and weight loss. You should also seek medical attention if you experience symptoms of digoxin toxicity such as nausea, vomiting, blurred vision, slow pulse, or irregular heartbeats. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Excessive dosing of vitamin D can induce hypercalcemia, which may increase the risk of digitalis toxicity and serious arrhythmias due to additive inotropic effects.

MANAGEMENT: Caution is advised if digitalis compounds are used concomitantly with vitamin D or vitamin D analogs. Serum digoxin, calcium, and phosphorus levels should be closely monitored, especially early in treatment during dosage adjustment. The serum calcium X phosphorus product should be maintained at less than 55 in patients with chronic kidney disease and should not be allowed to exceed 70 in any patient. An estimate of daily dietary calcium intake should be made and the intake adjusted when indicated. Patients should be advised to avoid an abrupt increase in dietary calcium intake, as it may trigger hypercalcemia, and to contact their physician if they experience early symptoms of vitamin D intoxication associated with hypercalcemia such as weakness, fatigue, headache, somnolence, vertigo, tinnitus, anorexia, nausea, vomiting, constipation, dry mouth, metallic taste, muscle pain, bone pain, ataxia, and hypotonia. Late symptoms may include polyuria, polydipsia, weight loss, nocturia, conjunctivitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, and cardiac arrhythmias. Patients should also seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

Digox

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digox (Oral), Digox Tablets

What is Digox?

Zolate

Generic Name: cholecalciferol / folic acid

Brand name: Ortho D, Zolate, Ortho DF, Genicin Vita-D

Synonyms: n.a.

What is Zolate?