Digox Tablets and Dronedarone

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using digoxin together with dronedarone. Combining these medications may significantly increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with dronedarone may significantly increase the serum concentrations of digoxin. The proposed mechanism is dronedarone inhibition of the P-glycoprotein-mediated renal tubular secretion of digoxin. According to the product labeling, dronedarone increased digoxin systemic exposure (AUC) by 2.5-fold. Gastrointestinal disorders were increased during coadministration in clinical trials for dronedarone. Conversely, digoxin can potentiate the electrophysiologic effects of dronedarone, such as decreased AV node conduction. In separate studies of patients with recently decompensated heart failure and patients with permanent atrial fibrillation, baseline use of digoxin was associated with an increased risk of arrhythmic or sudden death in patients receiving dronedarone compared to those receiving placebo. In patients not taking digoxin, no difference in risk of sudden death was observed in the dronedarone group relative to the placebo group.

MANAGEMENT: The need for digoxin therapy should be reconsidered prior to initiating dronedarone. If coadministration is deemed necessary, the digoxin dose should be reduced by one-half, and serum digoxin levels and pharmacologic effects closely monitored. Patients should be advised to notify their physician if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

Digox Tablets

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digox (Oral)

What is Digox Tablets?

Dronedarone

Generic Name: dronedarone

Brand name: Multaq

Synonyms: n.a.

What is Dronedarone?