Digoxin and ProAir RespiClick

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using albuterol together with digoxin may decrease the blood levels of digoxin. Albuterol may also decrease your potassium blood levels and put you at an increased risk of an irregular heart rhythm that may be serious and potentially life-threatening. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances. The risk may exist even when albuterol or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Do not exceed the dose and frequency of use recommended on the product label or prescribed by your doctor. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with albuterol decreases digoxin's serum concentration. The mechanism of action may involve an albuterol-induced increased distribution of digoxin to skeletal muscle. In a pharmacokinetic study, ten healthy patients were administered digoxin 0.5 mg daily for 10 days and then they were administered a single 3 mg or 4 mg oral dose of albuterol. This study reported a 22% decrease in serum digoxin levels and a 14% decrease in serum potassium after the albuterol dose. In addition, the effects of hypokalemia caused by beta-2 agonists such as albuterol may lead to an increased risk of digitalis induced arrhythmias. The clinical significance for patients who are receiving albuterol inhalation and digoxin is unclear.

MANAGEMENT: Caution is advised if albuterol is used concomitantly with digoxin. Monitoring of serum digoxin and potassium concentrations may be required. Clinical monitoring for digoxin toxicity and/or hypokalemia, particularly in patients at risk of hypokalemia should also be considered. Dosage adjustments for either medication may also be required whenever digoxin and albuterol are used concurrently. Patients should be advised to seek immediate medical attention if they experience signs of arrhythmias, such as sudden dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeats.

Digoxin

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: n.a.

What is Digoxin?

ProAir RespiClick

Generic Name: albuterol

Brand name: ProAir HFA, ProAir RespiClick, Proventil HFA, Ventolin HFA, Accuneb, ProAir Digihaler, Proventil, VoSpire ER

Synonyms: ProAir Respiclick

What is ProAir RespiClick?