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Digoxin and Reglan (Metoclopramide Injection Solution)

Determining the interaction of Digoxin and Reglan (Metoclopramide Injection Solution) and the possibility of their joint administration.

Check result:

Digoxin <> Reglan (Metoclopramide Injection Solution)

Relevance: 18.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Digoxin serum concentrations may be reduced during concomitant therapy with metoclopramide. The proposed mechanism is metoclopramide-induced stimulation of gastric motility, which may decrease digoxin absorption. Rapidly dissolving preparations such as digoxin solution in capsules do not appear to be affected. Patients should be advised to notify their physicians if they experience worsening of their heart symptoms.

References

Kirch W, Janisch HD, Santos SR, Duhrsen U, Dylewicz P, Ohnhaus EE "Effect of cisapride and metoclopramide on digoxin bioavailability." Eur J Drug Metab Pharmacokinet 11 (1986): 249-50
Manninen V, Apajalahti A, Melin J, Karesoja M "Altered absorption of digoxin in patients given propantheline and metoclopramide." Lancet 1 (1973): 398-400
"Product Information. Lanoxicaps (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.
Manninen V, Apajalahti A, Simonen H, Reissell P "Effect of propantheline and metoclopramide on absorption of digoxin." Lancet 1 (1973): 1118-9
Medin S, Nyberg L "Effect of propantheline and metoclopramide on absorption of digoxin." Lancet 1 (1973): 1393
Johnson BF, Bustrack JA, Urbach DR, Hull JH, Marwaha R "Effect of metoclopramide on digoxin absorption from tablets and capsules." Clin Pharmacol Ther 36 (1984): 724-30
Greiff JMC, Rowbotham D "Pharmacokinetic drug interactions with gastrointestinal motility modifying agents." Clin Pharmacokinet 27 (1994): 447-61
Fraser EJ, Leach RH, Poston JW, Bold AM, Culank LS, Lipede AB "Dissolution-rates and bioavailability of digoxin tablets." Lancet 1 (1973): 1393
Johnson BF, O'Grady J, Bye C "The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide." Br J Clin Pharmacol 5 (1978): 465-7

Digoxin

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: n.a.

What is Digoxin?

Reglan (Metoclopramide Injection Solution)

Generic Name: metoclopramide

Brand name: Reglan, Metozolv ODT

Synonyms: Reglan

What is Reglan (Metoclopramide Injection Solution)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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