Digoxin and Sitagliptin Phosphate
Determining the interaction of Digoxin and Sitagliptin Phosphate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with sitagliptin does not appear to significantly alter the pharmacokinetics of digoxin. Following administration of digoxin 0.25 mg concomitantly with sitagliptin 100 mg daily for 10 days, the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of digoxin were increased by 18% and 11%, respectively.
- "Product Information. Januvia (sitagliptin)." Merck & Company Inc, West Point, PA.
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: n.a.
Generic Name: sitagliptin
Brand name: Januvia
Synonyms: Sitagliptin, SitaGLIPtin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Digoxin-Sitavig
- Digoxin-Sivextro
- Digoxin-Sivextro (Tedizolid Injection)
- Digoxin-Sivextro (Tedizolid Tablets)
- Digoxin-Sivextro Intravenous
- Digoxin-Sivextro tablet, film coated; lyophilized powder for injection
- Sitagliptin Phosphate-Digoxin immune FAB
- Sitagliptin Phosphate-Digoxin Immune Fab (Ovine)
- Sitagliptin Phosphate-Digoxin Injection
- Sitagliptin Phosphate-Digoxin Intravenous
- Sitagliptin Phosphate-Digoxin Oral Solution
- Sitagliptin Phosphate-Digoxin oral/injection