Digoxin and Tigecycline

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Tigecycline does not significantly affect the pharmacokinetics of digoxin, and vice versa. In healthy subjects, coadministration of tigecycline (100 mg followed by 50 mg every 12 hours) and digoxin (0.5 mg followed by 0.25 mg orally every 24 hours) resulted in a 13% decrease in the peak plasma concentration (Cmax) of digoxin. There was no change in the steady-state pharmacodynamic effects of digoxin as indicated by ECG interval measurements, and the systemic exposure (AUC) and clearance of digoxin were also not altered. Digoxin did not affect the pharmacokinetics of tigecycline. No dosage adjustment of either drug is necessary during coadministration.

Digoxin

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: n.a.

What is Digoxin?

Tigecycline

Generic Name: tigecycline

Brand name: Tygacil

Synonyms: n.a.

What is Tigecycline?