Digoxin Immune Fab (Ovine) and Dofetilide
Determining the interaction of Digoxin Immune Fab (Ovine) and Dofetilide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using dofetilide together with digoxin immune FAB can increase the risk of an irregular heart rhythm that may be serious. If your doctor prescribes these medications together, you may need regular monitoring of your electrolyte (magnesium, potassium) levels as well as other tests to safely use both medications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with dofetilide. In addition, you should let your doctor know if you experience signs of electrolyte disturbance such as weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR CLOSELY: Dofetilide can cause dose- and concentration-related QT interval prolongation. Theoretically, coadministration with agents that can produce hypokalemia and/or hypomagnesemia (e.g., potassium-wasting diuretics, amphotericin B, cation exchange resins, stimulant laxatives) may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential.
MANAGEMENT: Caution is advised if dofetilide must be used concomitantly with medications that can cause potassium and/or magnesium disturbances. Serum electrolytes should be evaluated and any abnormalities corrected prior to initiating therapy with dofetilide. During therapy, potassium concentrations should be kept above 4 mEq/dL and magnesium concentrations above 1.8 mg/dL. Patients should also have frequent ECGs and be monitored for serious arrhythmias when QT intervals are prolonged. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, or syncope.
- "Product Information. Tikosyn (dofetilide)" Pfizer US Pharmaceuticals, Atlanta, GA.
Generic Name: digoxin immune fab
Brand name: DigiFab, Digibind
Synonyms: Digoxin immune FAB, Digoxin Immune Fab
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Digoxin Immune Fab (Ovine)-DOK
- Digoxin Immune Fab (Ovine)-Dok Plus
- Digoxin Immune Fab (Ovine)-Dolasetron
- Digoxin Immune Fab (Ovine)-Dolasetron Injection
- Digoxin Immune Fab (Ovine)-Dolasetron Mesylate
- Digoxin Immune Fab (Ovine)-Dolasetron Oral, Intravenous
- Dofetilide-Digoxin Injection
- Dofetilide-Digoxin Intravenous
- Dofetilide-Digoxin Oral Solution
- Dofetilide-Digoxin oral/injection
- Dofetilide-Digoxin Tablets
- Dofetilide-Dihydro CP Syrup