Digoxin Injection and Minocycline Hydrochloride eent
Determining the interaction of Digoxin Injection and Minocycline Hydrochloride eent and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking minocycline, tell your doctor if you also use digoxin. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase digoxin levels. You should notify your doctor if you have symptoms of nausea, loss of appetite, visual changes, slow pulse, or irregular heartbeats. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Tetracyclines may increase serum levels of orally administered digoxin in about 10% of the population. The mechanism may be related to changes in intestinal flora that alter the absorption of digoxin. The risk of an interaction may be less with digoxin solution in capsules because absorption occurs in the upper GI tract.
MANAGEMENT: Clinical monitoring of patient response and tolerance, including laboratory serum digoxin levels is recommended. Digoxin dosage reductions may be required. Patients should be advised to notify their physicians if they experience nausea, anorexia, visual changes, slow pulse, or irregular heartbeats.
- Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
- "Product Information. Lanoxicaps (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.
- Lindenbaum J, Tse-Eng D, Butler VP, Rund DG "Urinary excretion of reduced metabolites of digoxin." Am J Med 71 (1981): 67-74
- Lindenbaum J, Rund DG, Butler VP Jr, Tse-Eng D, Saha JR "Inactivation of digoxin by the gut flora: reversal by antibiotic therapy." N Engl J Med 305 (1981): 789-94
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: Digoxin
Generic Name: minocycline
Brand name: Dynacin, Minocin, Minocin PAC, Minolira, Solodyn, Ximino, Vectrin, Myrac
Synonyms: Minocycline, Minocycline (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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