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Digoxin Injection and Revlimid

Determining the interaction of Digoxin Injection and Revlimid and the possibility of their joint administration.

Check result:

Digoxin Injection <> Revlimid

Relevance: 07.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Lenalidomide may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with lenalidomide may increase the plasma concentrations of digoxin. The mechanism of interaction is unknown. Lenalidomide did not significantly affect the systemic exposure (AUC) of digoxin when administered together but increased digoxin peak plasma concentration (Cmax) by 14%.

MANAGEMENT: It may be appropriate to monitor pharmacologic response and serum digoxin levels more closely whenever lenalidomide is added to or withdrawn from therapy, and the digoxin dosage adjusted as necessary. Patients should be advised to notify their physician if they experience signs and symptoms of digoxin toxicity such as irregular heartbeats, slow pulse, nausea, anorexia, or visual changes.

References

"Product Information. Revlimid (lenalidomide)." Celgene Corporation, Summit, NJ.

Digoxin Injection

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digoxin Injection?

Revlimid

Generic Name: lenalidomide

Brand name: Revlimid

Synonyms: n.a.

What is Revlimid?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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