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Digoxin Injection and Xanax

Determining the interaction of Digoxin Injection and Xanax and the possibility of their joint administration.

Check result:
Digoxin Injection <> Xanax
Relevance: 07.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

ALPRAZolam may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Benzodiazepines may increase serum levels of digoxin. The mechanism is unknown, but may be related to alterations of digoxin protein binding. Data have been conflicting; however, some cases of digoxin toxicity have been reported. Elderly patients may have a greater risk of developing toxicity.

MANAGEMENT: Close observation for clinical and laboratory evidence of digoxin toxicity is recommended if these drugs must be used together. Patients should be advised to notify their physician if they experience nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeats.

References
  • Tollefson G, Lesar T, Grothe D, Garvey M "Alprazolam-related digoxin toxicity." Am J Psychiatry 141 (1984): 1612-3
  • Ochs HR, Greenblatt DJ, Verburg-Ochs B "Effect of alprazolam on digoxin kinetics and creatinine clearance." Clin Pharmacol Ther 38 (1985): 595-8
  • Tollefson G, Lesar T, Grothe D, Garvey M "Alprazolam-related digoxin toxicity." Am J Psychiatry 141 (1984): 1612-4
  • Castillo-Ferrando JR, Prieto AC, Brasas F "Effects of benzodiazepines on digoxin tissue concentrations and plasma protein binding." J Pharm Pharmacol 35 (1983): 462-3
  • Castillo-Ferrando JR, Garcia M, Carmona J "Digoxin levels and diazepam." Lancet 2 (1980): 368
  • Guven H, Tuncok Y, Guneri S, Cavdar C, Fowler J "Age-related digoxin-alprazolam interaction." Clin Pharmacol Ther 54 (1993): 42-4
  • Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
Digoxin Injection

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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