Digoxin Intravenous and Lapatinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using digoxin together with lapatinib. Combining these medications may significantly increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration with lapatinib may significantly increase the plasma concentrations of digoxin. The proposed mechanism is lapatinib inhibition of the P-glycoprotein-mediated intestinal efflux and/or renal tubular secretion of digoxin. When single-dose digoxin was coadministered with lapatinib, digoxin systemic exposure (AUC) increased by approximately 2.8-fold.

MANAGEMENT: Caution is advised if digoxin is used in combination with lapatinib. Serum digoxin levels and pharmacologic effects should be closely monitored during coadministration and following the discontinuation of lapatinib, and the digoxin dosage adjusted as necessary. If digoxin serum concentration is above 1.2 ng/mL, the digoxin dosage should be reduced by one-half. Patients should be advised to notify their physician if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

Digoxin Intravenous

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digoxin Intravenous?

Lapatinib

Generic Name: lapatinib

Brand name: Tykerb

Synonyms: n.a.

What is Lapatinib?