Digoxin Intravenous and Neomycin Sulfate
Determining the interaction of Digoxin Intravenous and Neomycin Sulfate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Oral neomycin has been shown to decrease the absorption of oral digoxin. The effects of oral paromomycin and kanamycin are not known. The proposed mechanism is a neomycin-induced malabsorption syndrome resulting in reduced absorption of drugs. This effect may be offset by a subsequent decrease in digoxin metabolism. During concomitant therapy with any of these antibiotics, digoxin serum concentrations and efficacy should be monitored. Patients should be advised to notify their physician if they experience a worsening of their heart symptoms.
- Lindenbaum J, Tse-Eng D, Butler VP, Rund DG "Urinary excretion of reduced metabolites of digoxin." Am J Med 71 (1981): 67-74
- Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
- Lindenbaum J, Maulitz RM, Butler VP "Inhibition of digoxin absorption by neomycin." Gastroenterology 71 (1976): 399-404
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: Digoxin
Generic Name: neomycin
Brand name: Neo-Fradin, Neo-Tab, Mycifradin
Synonyms: Neomycin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Digoxin Intravenous-Neomycin Sulfate topical
- Digoxin Intravenous-Neomycin Tablets
- Digoxin Intravenous-Neomycin Topical
- Digoxin Intravenous-Neomycin, Colistin, Hydrocortisone, and Thonzonium
- Digoxin Intravenous-Neomycin, polymyxin b, and bacitracin Topical
- Digoxin Intravenous-Neomycin, Polymyxin B, and Dexamethasone Eye Drops
- Neomycin Sulfate-Digoxin Oral Solution
- Neomycin Sulfate-Digoxin oral/injection
- Neomycin Sulfate-Digoxin Tablets
- Neomycin Sulfate-Dihydro CP Syrup
- Neomycin Sulfate-Dihydrocodeine BPM Phenyleph HCl
- Neomycin Sulfate-Dihydrocodeine, Aspirin, and Caffeine