Digoxin oral/injection and Tambocor
Determining the interaction of Digoxin oral/injection and Tambocor and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Flecainide may cause a slight increase in plasma digoxin levels. The mechanism is unknown. In one case, an increase in the PR interval was associated with this interaction, but no clinically significant adverse effects have been reported. If digoxin levels are in the upper end of the therapeutic range before flecainide is administered, caution is recommended. If digoxin toxicity develops or is suspected during coadministration, a decrease in digoxin dosage should be considered. Patients should be advised to notify their physician if they experience nausea, anorexia, visual changes, slow pulse, or irregular heartbeats.
- Lewis GP, Holtzman JL "Interaction of flecainide with digoxin and propranolol." Am J Cardiol 53 (1984): b52-7
- Weeks CE, Conard GJ, Kvam DC, et al "The effect of flecainide acetate, a new antiarrhythmic, on plasma digoxin levels." J Clin Pharmacol 26 (1986): 27-31
- Lewis GP, Holtzman JL "Interaction of flecainide with digoxin and propranolol." Am J Cardiol 53 (1984): b52-7
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: Digoxin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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