Digoxin Oral Solution and Epclusa

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Velpatasvir may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with velpatasvir may increase the serum concentrations of digoxin. The proposed mechanism is velpatasvir inhibition of the P-glycoprotein-mediated intestinal or renal efflux of digoxin. When a single 0.25 mg dose of digoxin was administered with velpatasvir 100 mg to 21 healthy volunteers, mean digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 1.9- and 1.3-fold, respectively.

MANAGEMENT: Serum digoxin levels and pharmacologic effects should be closely monitored following the addition or withdrawal of sofosbuvir-velpatasvir, and the digoxin dosage adjusted as needed. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

Digoxin Oral Solution

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digoxin Oral Solution?

Epclusa

Generic Name: sofosbuvir / velpatasvir

Brand name: Epclusa

Synonyms: n.a.

What is Epclusa?