Digoxin Tablets and Milnacipran

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using digoxin together with milnacipran. Milnacipran can increase your blood pressure and heart rate, which may negatively affect your heart condition. If your doctor prescribes these medications together, you may need a dose adjustment or more frequent monitoring of your blood pressure and pulse to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Use of milnacipran concomitantly with digoxin may be associated with potentiation of adverse hemodynamic effects. Inhibition of norepinephrine and serotonin reuptake by milnacipran can lead to cardiovascular effects including sustained increases in blood pressure and heart rate. However, effects of milnacipran in patients with significant hypertension, arrhythmia, or cardiac disease have not been systematically evaluated. Postural hypotension and tachycardia have been reported in combination therapy with intravenously administered digoxin (1 mg). No pharmacokinetic interaction was observed between milnacipran (200 mg/day) and digoxin (0.2 mg/day Lanoxicaps) following multiple-dose administration to healthy subjects.

MANAGEMENT: Coadministration of milnacipran and intravenous digoxin should be avoided. Caution is advised during coadministration with oral digoxin therapy. Blood pressure and heart rate should be measured prior to initiating milnacipran and periodically throughout treatment. A dosage reduction or discontinuation should be considered in patients who experience a sustained increase in blood pressure or heart rate while receiving milnacipran.

Digoxin Tablets

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digoxin Tablets?

Milnacipran

Generic Name: milnacipran

Brand name: Savella, Savella Titration Pack

Synonyms: n.a.

What is Milnacipran?