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Digoxin Tablets and Sodium polystyrene sulfonate Rectal

Determining the interaction of Digoxin Tablets and Sodium polystyrene sulfonate Rectal and the possibility of their joint administration.

Check result:
Digoxin Tablets <> Sodium polystyrene sulfonate Rectal
Relevance: 13.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

By lowering potassium levels in the blood, sodium polystyrene sulfonate may increase sensitivity of the heart to the effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if you experience dizziness, lightheadedness, fainting, constipation, abdominal cramping, confusion, muscle weakness, muscle cramps, numbness or tingling, or rapid heart beat, as these may be early symptoms of low potassium blood levels. You should seek immediate medical attention if you experience signs and symptoms that may indicate excessive effects of digoxin, such as nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cation exchange resins may increase the risk of precipitating hypokalemia and cardiotoxic effects when administered to a patient also receiving cardiac glycosides. The mechanism is the pharmacologic action of exchange resins (increased potassium excretion).

MANAGEMENT: Serum potassium levels should be closely monitored if these agents must be coadministered.

References
  • "Product Information. Kayexalate (sodium polystyrene sulfonate)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Digoxin Tablets

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

Sodium polystyrene sulfonate Rectal

Generic Name: sodium polystyrene sulfonate

Brand name: Kalexate, Kayexalate, Kionex

Synonyms: Sodium polystyrene sulfonate (Rectal)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.