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Dihydroergotamine injection and Nitrolingual

Determining the interaction of Dihydroergotamine injection and Nitrolingual and the possibility of their joint administration.

Check result:

Dihydroergotamine injection <> Nitrolingual

Relevance: 13.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using nitroglycerin together with dihydroergotamine. Using nitroglycerin together with dihydroergotamine can increase the effects of dihydroergotamine. Contact your doctor immediately if you experience an irregular heartbeat, nausea, vomiting, weakness, or coldness, numbness, or pain in the hands, feet, arms, or legs. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Ergot alkaloids, by causing vasoconstriction, may theoretically antagonize the effects of nitrates. In addition, nitrates may increase splanchnic blood flow, resulting in decreased first-pass metabolism of dihydroergotamine and increased bioavailability.

MANAGEMENT: This combination should generally be avoided. Ergot alkaloids are considered contraindicated in patients with ischemic heart disease.

References

Raberger G, Schutz W, Zimpfer M, Kraupp O "The influence of dihydroergotamine on adenosine-induced and reactive coronary vasodilation. Interaction of dihydroergotamine and coronary vasodilation." Basic Res Cardiol 71 (1976): 645-51
"Product Information. D.H.E. 45 (dihydroergotamine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Bobik A, Jennings G, Skews H, Esler M, McLean A "Low oral bioavailability of dihydroergotamine and first-pass extraction in patients with orthostatic hypotension." Clin Pharmacol Ther 30 (1981): 673-9

Dihydroergotamine injection

Generic Name: dihydroergotamine

Brand name: DHE. 45, Migranal

Synonyms: Dihydroergotamine (injection), Dihydroergotamine

What is Dihydroergotamine injection?

Nitrolingual

Generic Name: nitroglycerin

Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: n.a.

What is Nitrolingual?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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