Dihydroergotamine Mesylate and Isosorbide Mononitrate Extended Release
Determining the interaction of Dihydroergotamine Mesylate and Isosorbide Mononitrate Extended Release and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using isosorbide mononitrate together with dihydroergotamine. Using isosorbide mononitrate together with dihydroergotamine can increase the effects of dihydroergotamine. Contact your doctor immediately if you experience an irregular heartbeat, nausea, vomiting, weakness, or coldness, numbness, or pain in the hands, feet, arms, or legs. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Ergot alkaloids, by causing vasoconstriction, may theoretically antagonize the effects of nitrates. In addition, nitrates may increase splanchnic blood flow, resulting in decreased first-pass metabolism of dihydroergotamine and increased bioavailability.
MANAGEMENT: This combination should generally be avoided. Ergot alkaloids are considered contraindicated in patients with ischemic heart disease.
- Raberger G, Schutz W, Zimpfer M, Kraupp O "The influence of dihydroergotamine on adenosine-induced and reactive coronary vasodilation. Interaction of dihydroergotamine and coronary vasodilation." Basic Res Cardiol 71 (1976): 645-51
- "Product Information. D.H.E. 45 (dihydroergotamine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- Bobik A, Jennings G, Skews H, Esler M, McLean A "Low oral bioavailability of dihydroergotamine and first-pass extraction in patients with orthostatic hypotension." Clin Pharmacol Ther 30 (1981): 673-9
Generic Name: dihydroergotamine
Brand name: DHE. 45, Migranal
Synonyms: Dihydroergotamine (injection), Dihydroergotamine
Generic Name: isosorbide mononitrate
Brand name: Imdur, Monoket, ISMO
Synonyms: Isosorbide Mononitrate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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