About us Contacts Drug interactions: 390 212
Drug search by name

Dilantin and Loxapine Succinate

Determining the interaction of Dilantin and Loxapine Succinate and the possibility of their joint administration.

Check result:
Dilantin <> Loxapine Succinate
Relevance: 17.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

One case report has suggested that loxapine may decrease serum phenytoin levels. The mechanism may be related to an increase in phenytoin metabolism. The clinical significance is unknown. If loxapine and phenytoin must be used together, close observation for clinical evidence of altered phenytoin effect is recommended. Patients should be advised to notify their physician if they experience loss of seizure control.

References
  • Ryan GM, Matthews PA "Phenytoin metabolism stimulated by loxapine." Drug Intell Clin Pharm 11 (1977): 428-9
Dilantin

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: n.a.

Loxapine Succinate

Generic Name: loxapine

Brand name: Loxitane, Adasuve

Synonyms: Loxapine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction