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Dilantin and Rubex

Determining the interaction of Dilantin and Rubex and the possibility of their joint administration.

Check result:

Dilantin <> Rubex

Relevance: 17.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using phenytoin together with DOXOrubicin. Combining these medications may reduce the blood levels and effects of phenytoin. You may need a dose adjustment if you have been taking phenytoin and are starting treatment with DOXOrubicin. Similarly, if DOXOrubicin is discontinued, your dosage of phenytoin may need to be readjusted. Contact your doctor if your condition changes or you experience loss of seizure control during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cases have been reported in which patients receiving chemotherapy have experienced markedly reduced plasma phenytoin concentrations and seizures. Other hydantoins may interact with chemotherapy in a similar manner. The mechanism of this interaction has not been clearly established. One study showed that the absorption of phenytoin decreased significantly during chemotherapy.

MANAGEMENT: It may be necessary to increase phenytoin dosage during chemotherapy and to decrease it after or between courses of chemotherapy. Intravenous phenytoin may be less likely to interact with chemotherapy. Careful monitoring of patients for seizure activity is recommended, as is monitoring of plasma phenytoin levels.

References

Jarosinski PF, Moscow JA, Alexander MS, et al "Altered phenytoin clearance during intensive chemotherapy for acute lymphoblastic leukemia." J Pediatr 112 (1988): 996-9
"Product Information. Oncovin (vincristine)." Lilly, Eli and Company, Indianapolis, IN.
Fincham RW, Schottelius DD "Decreased phenytoin levels in antineoplastic therapy." Ther Drug Monit 1 (1979): 277-83
Sylvester RK, Lewis FB, Caldwell KC, Lobell M, Perri R, Sawchuk RA "Impaired phenytoin bioavailability secondary to cisplantin, vinblastine, and bleomycin." Ther Drug Monit 6 (1984): 302-5
Grossman SA, Sheidler VR, Gilbert MR "Decreased phenytoin levels in patients receiving chemotherapy." Am J Med 87 (1989): 505-10
Dofferhoff AS, Berendsen HH "Decreased phenytoin level after carboplatin treatment." Am J Med 89 (1990): 247
Neef C, de Voogd-van der Straaten "An interaction between cytostatic and anticonvulsant drugs." Clin Pharmacol Ther 43 (1988): 372-5
Bollini P, Riva R, Albani F, Ida et al "Decreased phenytoin level during antineoplastic therapy: a case report." Epilepsia 24 (1983): 75-8

Dilantin

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Dilantin?

Rubex

Generic Name: doxorubicin

Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS

Synonyms: Doxorubicin, DOXOrubicin (Conventional)

What is Rubex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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