Dilantin and Zanaflex Capsule

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before taking phenytoin, tell your doctor if you also use tiZANidine. This combination may increase the phenytoin levels in your body. This combination may cause drowsiness, visual problems, seizures, changes in behavior, nausea, or poor muscle coordination. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special test if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: One case report suggests elevated phenytoin levels associated with concomitant tizanidine use. The mechanism is unknown, but postulated to be competitive inhibition of hepatic enzymes. Drowsiness was the only adverse effect noted, and a dosage reduction of 20% was required. A similar interaction may occur with other hydantoins.

MANAGEMENT: Until further information is available close clinical and laboratory monitoring for toxicity is recommended. Dose adjustment may be necessary if an interaction is suspected. Patients should be advised to notify their physician if they experience symptoms of possible hydantoin toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia.

Dilantin

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Dilantin?

Zanaflex Capsule

Generic Name: tizanidine

Brand name: Zanaflex

Synonyms: Tizanidine, TiZANidine

What is Zanaflex Capsule?