Dilantin-30 and Fludarabine Phosphate

• Generic Name: phenytoin
• Dosage Forms: capsule, extended release
• Other Brand Names: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Phenytoin is used to control seizures (convulsions) in the treatment of epilepsy. It is also used to prevent and treat seizures that occur during brain surgery. This medicine is an anticonvulsant that works in the brain tissue to stop seizures.

This medicine is available only with your doctor's prescription.

• Generic Name: fludarabine
• Dosage Forms: n.a.
• Other Brand Names: Fludara, Oforta

Treatment of B-cell CLL (B-CLL) in patients refractory to at least one standard alkylating agent-containing regimen (e.g., chlorambucil with or without prednisone) or whose disease has progressed during treatment; considered a drug of choice. Has been designated an orphan drug by FDA for this use.

Used in the management of previously untreated CLL (has been designated an orphan drug by FDA for this use) or in leukemia that was contemporaneously responsive to standard therapy.

Treatment of low-grade, advanced (stage III or IV) adult non-Hodgkin’s lymphoma that failed or relapsed after previous therapy; has been designated an orphan drug by FDA for use in this condition.

Treatment of either acute myeloid (myelogenous, nonlymphocytic) leukemia (AML, ANLL) or acute lymphocytic leukemia (ALL) refractory to conventional therapy or which has relapsed following remission.

Severe toxicity, associated with the relatively high dosages that appear to be necessary for adequate response in these leukemias, may preclude use of the drug as monotherapy for remission induction of these cancers.

Palliative treatment of prolymphocytic leukemia (PLL) or prolymphocytoid chronic lymphocytic leukemia (CLL-Pro) refractory to standard chemotherapy (e.g., chlorambucil and prednisone).

Treatment of hairy cell leukemia (leukemic reticuloendotheliosis); other drugs (e.g., cladribine, pentostatin) considered the initial therapies of choice.

Treatment of refractory macroglobulinemia.

Treatment of mycosis fungoides, a form of cutaneous T-cell lymphoma.