Dilantin-30 and Xylocaine MPF With Epinephrine
Determining the interaction of Dilantin-30 and Xylocaine MPF With Epinephrine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Hydantoins may increase the hepatic metabolism of intravenous lidocaine. Serum lidocaine levels may be decreased, and increased dosage may be necessary. Caution is recommended, however, since the possible myocardial-depressant effects of both drugs may be additive. Hemodynamic and electrocardiographic status should be monitored during therapy. No action is required unless an interaction is suspected.
- Heinonen J, Takki S, Jarho L "Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes." Acta Anaesthesiol Scand 14 (1970): 89-95
- Wood RA "Sinoatrial arrest: an interaction between phenytoin and lignocaine." Br Med J 1 (1971): 645
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Dilantin
Generic Name: epinephrine / lidocaine
Brand name: D-Care 100X, Lignospan Forte, Lignospan Standard, Xylocaine MPF With Epinephrine, Xylocaine With Epinephrine
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dilantin-30-Xylocaine Topical application
- Dilantin-30-Xylocaine Topical Solution
- Dilantin-30-Xylocaine With Epinephrine
- Dilantin-30-Xylometazoline
- Dilantin-30-Xylometazoline nasal
- Dilantin-30-Xylon
- Xylocaine MPF With Epinephrine-Dilatrate-SR
- Xylocaine MPF With Epinephrine-Dilaudid
- Xylocaine MPF With Epinephrine-Dilaudid (Hydromorphone Injection)
- Xylocaine MPF With Epinephrine-Dilaudid (Hydromorphone Liquid)
- Xylocaine MPF With Epinephrine-Dilaudid (Hydromorphone Suppository)
- Xylocaine MPF With Epinephrine-Dilaudid (Hydromorphone Tablets)