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Dilantin Infatabs and Fluarix Quadrivalent 2013-2014 Formula

Determining the interaction of Dilantin Infatabs and Fluarix Quadrivalent 2013-2014 Formula and the possibility of their joint administration.

Check result:
Dilantin Infatabs <> Fluarix Quadrivalent 2013-2014 Formula
Relevance: 04.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking phenytoin, tell your doctor if you also use influenza virus vaccine, inactivated. You may need dose adjustments or special tests in order to safely take both medications together. This combination may affect the phenytoin levels in your body. You should notify your doctor if you have symptoms such as drowsiness, visual disturbances, changes in behavior, nausea, or poor muscle coordination. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Influenza virus vaccine has been reported to exert a variety of effects on phenytoin pharmacokinetics. Both decreases and increases in phenytoin serum concentrations have both been reported. The mechanism is unknown.

MANAGEMENT: Close observation for clinical and laboratory evidence of altered phenytoin effect is recommended for at least 2 weeks after influenza virus vaccine is administered to a patient receiving phenytoin. Patients should be advised to notify their physician if they experience loss of seizure control or symptoms of phenytoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia).

References
  • Smith CD, Bledsoe MA, Curran R, Green L, Lewis J "Effect of influenza vaccine on serum concentrations of total and free phenytoin." Clin Pharm 7 (1988): 828-32
  • Grabenstein JD "Drug interactions involving immunologic agents. Part II. Immunodiagnostic and other immunologic drug interactions." DICP 24 (1990): 186-93
  • Sawchuk RJ, Rector TS, Fordice JJ, Leppik IE "Effect of influenza vaccination on plasma phenytoin concentrations." Ther Drug Monit 1 (1979): 285-8
  • Jann MW, Fidone GS "Effect of influenza vaccine on serum anticonvulsant concentrations." Clin Pharm 5 (1986): 817-20
Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

Fluarix Quadrivalent 2013-2014 Formula

Generic Name: influenza virus vaccine, inactivated

Brand name: Afluria, Agriflu, Fluad 2019-2020, Fluarix, Flublok Quadrivalent 2019-2020, Flucelvax, FluLaval, Fluogen, Flushield, Fluvirin, Fluzone, Flucelvax, Fluzone Intradermal Quadrivalent, Fluzone Quadrivalent, Flublok, Flublok Quadrivalent

Synonyms: Influenza virus vaccine (injection), Influenza Virus Vaccine (Inactivated)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.