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Dilantin Infatabs and Gencontuss

Determining the interaction of Dilantin Infatabs and Gencontuss and the possibility of their joint administration.

Check result:

Dilantin Infatabs <> Gencontuss

Relevance: 04.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using chlorpheniramine together with phenytoin can increase the effects of phenytoin. Contact your doctor if you experience drowsiness, visual disturbances, change in mental status, nausea, loss of muscle coordination, or involuntary movements. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Toxic serum concentrations of phenytoin and involuntary movements have been reported during coadministration with chlorpheniramine. Symptoms resolved after chlorpheniramine was discontinued. The mechanism of this interaction is not known.

MANAGEMENT: Clinical monitoring of patient response, tolerance, and serum phenytoin concentrations is recommended. Patients should be advised to notify their physician if they experience symptoms of phenytoin toxicity (drowsiness, visual disturbances, change in mental status, nausea, or ataxia) or involuntary movements.

References

Ahmad S, Laidlaw J, Houghton GW, Richens A "Involuntary movements caused by phenytoin intoxication in epileptic patients." J Neurol Neurosurg Psychiatry 38 (1975): 225-31
Pugh RN, Geddes AM, Yeoman WB "Interaction of phenytoin with chlorpheniramine." Br J Clin Pharmacol 2 (1975): 173-5

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?

Gencontuss

Generic Name: chlorpheniramine / dextromethorphan / phenylephrine

Brand name: Alka-Seltzer Plus Cold and Cough, Balamine DM, Ed A-Hist DM, Gencontuss, Giltuss Allergy Plus, NoHist DM, Robitussin Cough & Allergy, Cerose DM, Tussar DM, Liquituss R-DM, Atuss DM, Norel DM, Poly-Tussin DM, De-Chlor DM, De-Chlor DR, Coldtuss-DR, Tri-Vent DPC, Atuss DR, Corfen-DM, Uni-Tuss DM, Mintuss DR, Trital DM, P Chlor DM, Dex PC, Rondec-DM Drops, Rondec-DM, Donatussin DM Drops, Ceron-DM Drops, Ceron-DM, Rondex-DM, Rondex-DM Drops, Dec-Chlorphen DM, Dec-Chlorphen DM Drops, HistadecDM, CP Dec DM, Neo DM Drops, Cardec DM Drops, Reme Tussin DM, Maxiphen ADT, Tussplex DM, Robitussin Pediatric Cough & Cold Nighttime, Robitussin Cough & Cold Nighttime, Cardec DM, C-Phen DM, C-Phen DM Drops, Sildec-PE DM Drops, Sildec-PE DM, Nasohist-DM, DM-PE-Chlor, CP Dec-DM Drops, PD-Cof Drops, PD-Cof, Zotex-12D, Quartuss DM, Nohist-DMX, Sonahist-DM, Relahist-DM, Z-Dex 12 D, Bronkids, Statuss DM, Albatussin SR, NoHist-PDX, Re DCP, Centergy DM, Zoden DM Drops, Trigofen DM Drops, Nasohist-DM Pediatric, Tri-Dex PE, Virdec DM, Norel CS, EndaCof Drops, Giltuss Children's Allergy Plus, Maxichlor PEH DM

Synonyms: n.a.

What is Gencontuss?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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