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Dilantin Infatabs and Lanoxin (Digoxin Injection)

Determining the interaction of Dilantin Infatabs and Lanoxin (Digoxin Injection) and the possibility of their joint administration.

Check result:

Dilantin Infatabs <> Lanoxin (Digoxin Injection)

Relevance: 04.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with digoxin may cause digoxin to clear your body faster. You may need dose adjustments or special tests in order to safely take both medications together. The risk of digoxin toxicity may be increased when phenytoin is stopped. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Limited clinical data suggest that hydantoins may reduce digoxin serum levels. The mechanism of this interaction is unknown. Although phenytoin has been used in the treatment of digitalis-induced arrhythmias, it has been associated with cardiac arrest in patients with marked heart block.

MANAGEMENT: If these drugs are used concomitantly, close monitoring for clinical and laboratory evidence of altered digitalis effect is recommended. Occasionally, increases in the digoxin dosage may be necessary. The clinician should be aware that the risk of digoxin toxicity may be increased when a hydantoin is discontinued and should consider monitoring the patient more closely for those effects. Phenytoin should be avoided in patients with marked digoxin-induced heart block or bradycardia.

References

Solomon HM, Abrams WB "Interactions between digitoxin and other drugs in man." Am Heart J 83 (1972): 277-80
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Allonen H, Iisalo E, Nuortio L "Effect of reserpine, desipramine and phenytoin on digoxin induced arrhythmias and myocardial uptake of digoxin in guinea pigs." Acta Pharmacol Toxicol (Copenh) 37 (1975): 8-16
Rameis H "The importance of prospective planning of pharmacokinetic trials." Int J Clin Pharmacol Ther Toxicol 30 (1992): 528-9
Rameis H "The importance of prospective planning of pharmacokinetic trials. Considerations of studies on the phenytoin-digoxin-(P-D) and phenytoin-digitoxin-(P-DT) interaction." Int J Clin Pharmacol Ther Toxicol 30 (1992): 528-9
Cerner Multum, Inc. "Australian Product Information." O 0
Rameis H "On the interaction between phenytoin and digoxin." Eur J Clin Pharmacol 29 (1985): 49-53
Allonen H "The effect of phenytoin on the tissue concentrations of digoxin in the rat." Acta Pharmacol Toxicol (Copenh) 41 (1977): 481-8
"Product Information. Lanoxin (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Cerebyx (fosphenytoin)." Parke-Davis, Morris Plains, NJ.
Viukari NM, Aho K "Digoxin-phenytoin interaction." Br Med J 2 (1970): 51
Rumack BH, Wolfe RR, Gilfrich H "Phenytoin (diphenylhydantoin) treatment of massive digoxin overdose." Br Heart J 36 (1974): 405-8
Solomon HM, Reich S, Spirt N, Abrams WB "Interactions between digitoxin and other drugs in vitro and in vivo." Ann N Y Acad Sci 179 (1971): 362-8

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?

Lanoxin (Digoxin Injection)

Generic Name: digoxin

Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin

Synonyms: Lanoxin

What is Lanoxin (Digoxin Injection)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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