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Dilantin Infatabs and Pacerone

Determining the interaction of Dilantin Infatabs and Pacerone and the possibility of their joint administration.

Check result:

Dilantin Infatabs <> Pacerone

Relevance: 04.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking amiodarone, tell your doctor if you also use phenytoin. You may need dose adjustments or special tests in order to safely take both medications together. The phenytoin blood levels and amiodarone effectiveness may need evaluated for several weeks after starting therapy. You should notify your doctor if you have symptoms such as drowsiness, visual problems, changes in behavior, nausea, poor muscle coordination, or a worsening of your heart condition. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Amiodarone may decrease the hepatic metabolism of hydantoins, resulting in increased serum concentrations. Phenytoin may induce the hepatic metabolism of amiodarone, resulting in decreased serum amiodarone concentrations.

MANAGEMENT: Management consists of monitoring serum hydantoin concentrations and amiodarone effectiveness for several weeks after beginning therapy. Patients should be advised to notify their physician if they experience symptoms of toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia) or a worsening of their arrhythmia.

References

Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23
Ahmad S "Amiodarone and phenytoin: interaction." J Am Geriatr Soc 43 (1995): 1449-50
Nolan PE, Marcus FI, Karol MD, Hoyer GL, Gear K "Effect of phenytoin on the clinical pharmacokinetics of amiodarone." J Clin Pharmacol 30 (1990): 1112-9
Nolan PE, Marcus FI, Hoyer GL, et al "Pharmacokinetic interaction between intravenous phenytoin and amiodarone in healthy volunteers." Clin Pharmacol Ther 46 (1989): 43-50
Gore JM, Haffajee CI, Alpert JS "Interaction of amiodarone and diphenylphydantoin." Am J Cardiol 54 (1984): 1145
Nolan PE Jr, Erstad BL, Hoyer GL, Bliss M, Gear K, Marcus FI "Steady-state interaction between amiodarone and phenytoin in normal subjects." Am J Cardiol 65 (1990): 1252-7
Wilson JS, Podrid PJ "Side effects from amiodarone." Am Heart J 121 (1991): 158-71
Funck-Brentano C, Jacqz-Aigrain E, Leenhardt A, Roux A, Poirier JM, Jaillon P "Influence of amiodarone on genetically determined drug metabolism in humans." Clin Pharmacol Ther 50 (1991): 259-66
McGovern B, Geer VR, LaRaia PJ, et al "Possible interaction between amiodarone and phenytoin." Ann Intern Med 101 (1984): 650-1

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?

Pacerone

Generic Name: amiodarone

Brand name: Pacerone, Cordarone, Nexterone

Synonyms: n.a.

What is Pacerone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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