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Dilantin Infatabs and Sabril (Vigabatrin Oral Solution)

Determining the interaction of Dilantin Infatabs and Sabril (Vigabatrin Oral Solution) and the possibility of their joint administration.

Check result:

Dilantin Infatabs <> Sabril (Vigabatrin Oral Solution)

Relevance: 04.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with vigabatrin may modestly decrease the plasma concentrations of phenytoin. The exact mechanism of interaction is unknown, although in vitro drug metabolism studies indicate that it may involve induction of CYP450 2C isoenzymes in some patients. A gradual reduction of 16% to 33% in phenytoin plasma levels has been reported in controlled clinical studies of vigabatrin. These changes are unlikely to be of therapeutic significance in most patients, and phenytoin dose adjustments are not routinely required. However, a dose adjustment should be considered if an interaction is suspected.

References

Tassinari CA, Michelucci R, Ambrosetto G, Salvi F "Double-blind study of vigabatrin in the treatment of drug-resistant epilepsy." Arch Neurol 44 (1987): 907-10
Browne TR, Mattson RH, Penry JK, Smith DB, Treiman DM, Wilder BJ, Ben-Menachem E, Napoliello MJ, Sherry KM, Szabo GK "Vigabatrin for refractory complex partial seizures: multicenter single-blind study with long-term follow-up." Neurology 37 (1987): 184-9
"Product Information. Sabril (vigabatrin)." Lundbeck Inc, Deerfield, IL.
Rimmer EM, Richens A "Interaction between vigabatrin and phenytoin." Br J Clin Pharmacol 27(suppl 1 (1989): s27-33
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?

Sabril (Vigabatrin Oral Solution)

Generic Name: vigabatrin

Brand name: Sabril, Vigadrone

Synonyms: Sabril

What is Sabril (Vigabatrin Oral Solution)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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