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Dilantin Infatabs and Vecuronium Bromide

Determining the interaction of Dilantin Infatabs and Vecuronium Bromide and the possibility of their joint administration.

Check result:

Dilantin Infatabs <> Vecuronium Bromide

Relevance: 04.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenytoin together with vecuronium may cause vecuronium to be less effective. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Chronic oral administration of phenytoin may cause a resistance to the muscle-relaxant effects of vecuronium. Conversely, acute IV administration may increase neuromuscular blockade; however, the change may be clinically insignificant with normal phenytoin doses. The mechanism of this interaction is unknown.

MANAGEMENT: Close monitoring of neuromuscular blockade is recommended.

References

Gray HS, Slater RM, Pollard BJ "The effect of acutely administered phenytoin on vecuronium-induced neuromuscular blockade." Anaesthesia 44 (1989): 379-81
Baumgardner JE, Bagshaw R "Acute versus chronic phenytoin therapy and neuromuscular blockade." Anaesthesia 45 (1990): 493-4
Platt PR, Thackray NM "Phenytoin-induced resistance to vecuronium." Anaesth Intensive Care 21 (1993): 185-91
Ornstein E, Matteo RS, Schwartz AE, et al "The effect of phenytoin on the magnitude and duration of neuromuscular block following atracurium or vecuronium." Anesthesiology 67 (1987): 191-6

Dilantin Infatabs

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin Infatabs?

Vecuronium Bromide

Generic Name: vecuronium

Brand name: Vecuronium Bromide, Norcuron

Synonyms: Vecuronium

What is Vecuronium Bromide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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