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Dilor-400 and Pancuronium

Determining the interaction of Dilor-400 and Pancuronium and the possibility of their joint administration.

Check result:

Dilor-400 <> Pancuronium

Relevance: 05.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using dyphylline together with pancuronium may decrease the effects of pancuronium. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Methylxanthines may antagonize the effects of neuromuscular blockers. The mechanism is unknown. In patients stabilized on aminophylline, resistance to pancuronium has been reported.

MANAGEMENT: The patient should be monitored for adequate neuromuscular blockade and the dosage adjusted, if necessary.

References

Daller JA, Erstad B, Rosado L, Otto C, Putnam CW "Aminophylline antagonizes the neuromuscular blockade of pancuronium but not vecuronium." Crit Care Med 19 (1991): 983-5
Azar I, Kumar D, Betcher AM "Resistance to pancuronium in an asthmatic patient treated with aminophylline and steroids." Can Anaesth Soc J 29 (1982): 280-2
Doll DC, Rosenberg H "Antagonism of neuromuscular blockage by theophylline." Anesth Analg 58 (1979): 139-40

Dilor-400

Generic Name: dyphylline

Brand name:

Synonyms: n.a.

What is Dilor-400?

Pancuronium

Generic Name: pancuronium

Brand name:

Synonyms: n.a.

What is Pancuronium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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