Diltia XT and Lithium Citrate Syrup
Determining the interaction of Diltia XT and Lithium Citrate Syrup and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking dilTIAZem, tell your doctor if you also use lithium. You may need dose adjustments or special tests in order to safely take both medications together. You should notify your doctor if you have symptoms such as diarrhea, vomiting, drowsiness, tremor, thirst, lack of coordination, or muscle weakness. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Several case reports have suggested that the combination of lithium and calcium channel blockers may cause neurotoxicity and psychiatric effects such as psychosis. The mechanism is unknown. Data have been conflicting. Cases have been reported for diltiazem and verapamil.
MANAGEMENT: Patients who must take both drugs should be closely monitored for adverse neurologic and psychiatric effects. Patients should be advised to notify their physician if they experience symptoms of possible lithium toxicity such as drowsiness, dizziness, confusion, ataxia, vomiting, diarrhea, thirst, blurry vision, tinnitus, or tremor.
- Binder EF, Cayabyab L, Ritchie DJ, Birge SJ "Diltiazem-induced psychosis and a possible diltiazem-lithium interaction." Arch Intern Med 151 (1991): 373-4
- Valdiserri EV "A possible interaction between lithium and diltiazem: case report." J Clin Psychiatry 46 (1985): 540-1
- "Product Information. Eskalith (lithium)." SmithKline Beecham, Philadelphia, PA.
Generic Name: diltiazem
Brand name: Cardizem CD, Cartia XT, Dilt-XR, Diltia XT, Taztia XT, Tiazac, Cardizem, Dilacor XR, Dilt-CD, Diltzac, Matzim LA, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: n.a.
Generic Name: lithium
Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR
Synonyms: Lithium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diltia XT-Lithium Controlled-Release and Extended-Release Tablets
- Diltia XT-Lithium ER
- Diltia XT-Lithium Oral Solution
- Diltia XT-Lithium Salts
- Diltia XT-Lithium Syrup and Oral Solution
- Diltia XT-Lithobid
- Lithium Citrate Syrup-Diltiazem
- Lithium Citrate Syrup-Diltiazem 12-Hour Sustained-Release Capsules
- Lithium Citrate Syrup-Diltiazem CD
- Lithium Citrate Syrup-Diltiazem Extended Release Tablets
- Lithium Citrate Syrup-Diltiazem Hydrochloride
- Lithium Citrate Syrup-Diltiazem Injection