Diltia XT and Nifediac CC
Determining the interaction of Diltia XT and Nifediac CC and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking dilTIAZem, tell your doctor if you also use NIFEdipine. You may need dose adjustments or special tests in order to safely take both medications together . The levels of dilTIAZem or NIFEdipine may be increased. You should notify your doctor if you have symptoms of low blood pressure such as headaches, faint, or slow heartbeats. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Diltiazem may increase the bioavailability and decrease the metabolism of nifedipine. Serum levels and effect of nifedipine may be increased. In addition, nifedipine may increase plasma diltiazem concentrations. The pharmacologic effects of both medications may be additive. Increased risk of hypotension and conduction disturbances may result. The mechanism may be reduced hepatic clearance.
MANAGEMENT: If these agents must be used concomitantly, close monitoring for altered efficacy and safety is recommended. Dose adjustments may be required. Patients should be advised to notify their physician if they experience headaches, syncope, or slow heartbeats.
- Ohashi K, Tateishi T, Sudo T, et al "Effects of diltiazem on the pharmacokinetics of nifedipine." J Cardiovasc Pharmacol 15 (1990): 96-101
- Tateishi T, Ohashi K, Sudo T, et al "Dose dependent effect of diltiazem on the pharmacokinetics of nifedipine." J Clin Pharmacol 29 (1989): 994-7
- Toyosaki N, Toyo-oka T, Natsume T, et al. "Combination therapy with diltiazem and nifedipine in patients with effort angina pectoris." Circulation 77 (1988): 1370-5
Generic Name: diltiazem
Brand name: Cardizem CD, Cartia XT, Dilt-XR, Diltia XT, Taztia XT, Tiazac, Cardizem, Dilacor XR, Dilt-CD, Diltzac, Matzim LA, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: n.a.
Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: Nifediac CC (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diltia XT-Nifedical XL
- Diltia XT-Nifedipine
- Diltia XT-Nifedipine Capsules
- Diltia XT-Nifedipine Extended-Release Tablets
- Diltia XT-Niferex
- Diltia XT-Niferex Elixir
- Nifediac CC-Diltiazem
- Nifediac CC-Diltiazem 12-Hour Sustained-Release Capsules
- Nifediac CC-Diltiazem CD
- Nifediac CC-Diltiazem Extended Release Tablets
- Nifediac CC-Diltiazem Hydrochloride
- Nifediac CC-Diltiazem Injection