Diltia XT and Tacrolimus Extended-Release Tablets
Determining the interaction of Diltia XT and Tacrolimus Extended-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using tacrolimus together with dilTIAZem may increase the effects of tacrolimus. Contact your doctor if you experience increased side effects such as fever, infection, diarrhea, tremor, headache, fatigue, or lethargy. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: In vitro data suggest that some calcium channel blockers inhibit the CYP450 3A4 hepatic metabolism and produce elevated blood levels of macrolide immunosuppressants. In healthy subjects, diltiazem 120 mg increased the maximum plasma concentration of sirolimus 1.4-fold and the AUC 1.6-fold. In contrast, limited information suggests that verapamil concentrations may also increase when coadministered with sirolimus.
MANAGEMENT: Careful monitoring of macrolide immunosuppressant and possibly calcium channel blocker blood concentrations is recommended if these drugs must be used together. Dose reductions of the immunosuppressant may be required.
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Generic Name: diltiazem
Brand name: Cardizem CD, Cartia XT, Dilt-XR, Diltia XT, Taztia XT, Tiazac, Cardizem, Dilacor XR, Dilt-CD, Diltzac, Matzim LA, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: n.a.
Generic Name: tacrolimus
Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria
Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diltia XT-Tacrolimus Granules for Suspension
- Diltia XT-Tacrolimus Injection
- Diltia XT-Tacrolimus Intravenous
- Diltia XT-Tacrolimus oral and injection
- Diltia XT-Tacrolimus Oral, Intravenous
- Diltia XT-Tactinal
- Tacrolimus Extended-Release Tablets-Diltiazem
- Tacrolimus Extended-Release Tablets-Diltiazem 12-Hour Sustained-Release Capsules
- Tacrolimus Extended-Release Tablets-Diltiazem CD
- Tacrolimus Extended-Release Tablets-Diltiazem Extended Release Tablets
- Tacrolimus Extended-Release Tablets-Diltiazem Hydrochloride
- Tacrolimus Extended-Release Tablets-Diltiazem Injection