Diltiazem CD and Xanax XR Oral
Determining the interaction of Diltiazem CD and Xanax XR Oral and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:DilTIAZem may increase the blood levels and effects of ALPRAZolam. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with diltiazem may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by diltiazem.
MANAGEMENT: Caution is advised if diltiazem must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever diltiazem is added to or withdrawn from therapy.
- Sakai H, Kobayashi S, Hamada K, et al "The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates." Br J Clin Pharmacol 31 (1991): 353-5
- Sutton D, Butler AM, Nadin L, Murray M "Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites." J Pharmacol Exp Ther 282 (1997): 294-300
- Abernethy DR, Egan JM, Dickinson TH, Carrum G "Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans." J Pharmacol Exp Ther 244 (1988): 994-9
- Varis T, Backman JT, Kivisto KT, Neuvonen PJ "Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone." Clin Pharmacol Ther 67 (2000): 215-21
- Renton KW "Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil." Biochem Pharmacol 34 (1985): 2549-53
Generic Name: diltiazem
Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Dilt-XR, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: Diltiazem
Generic Name: alprazolam
Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol
Synonyms: Xanax XR
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diltiazem CD-XaQuil XR
- Diltiazem CD-Xarelto
- Diltiazem CD-Xarelto Starter Pack
- Diltiazem CD-Xartemis XR
- Diltiazem CD-Xartemix XR
- Diltiazem CD-Xatmep
- Xanax XR Oral-Diltiazem Extended Release Tablets
- Xanax XR Oral-Diltiazem Hydrochloride
- Xanax XR Oral-Diltiazem Injection
- Xanax XR Oral-Diltiazem Intravenous
- Xanax XR Oral-Diltiazem Long-Acting Capsules
- Xanax XR Oral-Diltiazem Long-Acting Tablets