Diltiazem Intravenous and Escitalopram Oral Solution
Determining the interaction of Diltiazem Intravenous and Escitalopram Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 is not expected to significantly affect the pharmacokinetics of citalopram or escitalopram, both of which are partially metabolized by the isoenzyme. Administration of racemic citalopram (40 mg) in combination with the potent CYP450 3A4 inhibitor ketoconazole (200 mg) decreased the ketoconazole peak plasma concentration (Cmax) by 21% and systemic exposure (AUC) by 10%, but did not significantly affect the pharmacokinetics of citalopram. Likewise, coadministration of a single 20 mg dose of escitalopram with a single 600 mg dose of ritonavir, another potent CYP450 3A4 inhibitor, did not affect the pharmacokinetics of either drug. Because citalopram and escitalopram are both metabolized by multiple isoenzymes (CYP450 2C19, 3A4, and 2D6), inhibition of a single isoenzyme may not appreciably decrease their clearance.
- "Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
- "Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
Generic Name: diltiazem
Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Dilt-XR, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Tiazac, Cardizem LA, Tiazac Extended Release Capsules
Synonyms: Diltiazem
Generic Name: escitalopram
Brand name: Lexapro
Synonyms: Escitalopram
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Diltiazem Intravenous-Escitalopram Oxalate
- Diltiazem Intravenous-Escitalopram Solution
- Diltiazem Intravenous-Escitalopram Tablets
- Diltiazem Intravenous-Esclim Transdermal
- Diltiazem Intravenous-Eserine
- Diltiazem Intravenous-Esgic
- Escitalopram Oral Solution-Diltiazem Long-Acting Capsules
- Escitalopram Oral Solution-Diltiazem Long-Acting Tablets
- Escitalopram Oral Solution-Diltiazem Tablets
- Escitalopram Oral Solution-Diltzac
- Escitalopram Oral Solution-Dimaphen DM
- Escitalopram Oral Solution-Dimaphen DM Cold/Cough