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Diltiazem Intravenous and Theo-Dur

Determining the interaction of Diltiazem Intravenous and Theo-Dur and the possibility of their joint administration.

Check result:

Diltiazem Intravenous <> Theo-Dur

Relevance: 07.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using dilTIAZem together with theophylline can increase the effects of theophylline. You should contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or an irregular heartbeat. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Diltiazem may inhibit the CYP450 3A4 hepatic metabolism of theophylline. Significant increases in serum theophylline levels may result. Data are limited.

MANAGEMENT: Clinical monitoring of patient response and tolerance and serum theophylline levels is recommended. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.

References

Smith SR, Haffner CA, Kendall MJ "The influence of nifedipine and diltiazem on serum theophylline concentration-time profiles." J Clin Pharm Ther 14 (1989): 403-8
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50
Ohashi K, Sakamoto K, Sudo T, Tateishi T, Fujimura A, Shiga T, Ebihara A "Effects of diltiazem and cimetidine on theophylline oxidative metabolism." J Clin Pharmacol 33 (1993): 1233-7
Nafziger AN, May JJ, Bertino JS Jr "Inhibition of theophylline elimination by diltiazem therapy." J Clin Pharmacol 27 (1987): 862-5
Soto J, Sacristan JA, Alsar MJ "Diltiazem treatment impairs theophylline elimination in patients with bronchospastic airway disease." Ther Drug Monit 16 (1994): 49-52
Christopher MA, Harman E, Hendeles L "Clinical relevance of the interaction of theophylline with diltiazem or nifedipine." Chest 95 (1989): 309-13
Abernethy DR, Egan JM, Dickinson TH, Carrum G "Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans." J Pharmacol Exp Ther 244 (1988): 994-9

Diltiazem Intravenous

Generic Name: diltiazem

Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Dilt-XR, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: Diltiazem

What is Diltiazem Intravenous?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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