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Diltiazem Intravenous and Tofranil

Determining the interaction of Diltiazem Intravenous and Tofranil and the possibility of their joint administration.

Check result:

Diltiazem Intravenous <> Tofranil

Relevance: 07.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using dilTIAZem and imipramine together may lower your blood pressure and slow your heart rate. This combination may cause uneven heartbeats, extreme drowsiness, dizziness, confusion, blurred vision, and muscle stiffness. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that diltiazem can increase the plasma concentrations of cyclic antidepressants. Data are available for nortriptyline, trimipramine, and imipramine. The proposed mechanism is inhibition of first-pass metabolism by diltiazem. ECG changes (first and second degree heart block) have been reported.

MANAGEMENT: Close monitoring for clinical response and tolerance is recommended whenever diltiazem is added to or discontinued from an antidepressant regimen. Patients should be advised to notify their physician if they experience excessive antidepressant effects such as dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or orthostatic hypotension. Dose adjustments may be necessary.

References

Krahenbuhl S, Smithgamble V, Hoppel CL "Pharmacokinetic interaction between diltiazem and nortriptyline." Eur J Clin Pharmacol 49 (1996): 417-9
Hermann DJ, Krol TF, Dukes GE, et al "Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine." J Clin Pharmacol 32 (1992): 176-83
Hermann DJ, Krol TF, Dukes GE, et al "Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine." J Clin Pharmacol 32 (1992): 176-83

Diltiazem Intravenous

Generic Name: diltiazem

Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Dilt-XR, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: Diltiazem

What is Diltiazem Intravenous?

Tofranil

Generic Name: imipramine

Brand name: Tofranil, Tofranil-PM

Synonyms: n.a.

What is Tofranil?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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