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Diltiazem Long-Acting Tablets and Nitropress

Determining the interaction of Diltiazem Long-Acting Tablets and Nitropress and the possibility of their joint administration.

Check result:

Diltiazem Long-Acting Tablets <> Nitropress

Relevance: 20.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The dosage of nitroprusside required to achieve a given hypotensive response is reduced by an average of 50% when diltiazem is coadministered. The mechanism is unknown. Since the risk of side effects from nitroprusside may be significantly decreased with a lower dose, this interaction may be advantageous.

References

Bernard JM, Moren J, Demeure D, Mommeril JL, Pinaud M "Diltiazem reduces the nitroprusside doses for deliberate hypotension." Anesthesiology 77 (1992): a427

Diltiazem Long-Acting Tablets

Generic Name: diltiazem

Brand name: Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Dilt-XR, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Tiazac, Cardizem LA, Tiazac Extended Release Capsules

Synonyms: Diltiazem

What is Diltiazem Long-Acting Tablets?

Nitropress

Generic Name: nitroprusside

Brand name: Nitropress, Nipride RTU

Synonyms: n.a.

What is Nitropress?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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