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Dimetapp, Childrens Non-Drowsy Allergy ODT and PCE Dispertab

Determining the interaction of Dimetapp, Childrens Non-Drowsy Allergy ODT and PCE Dispertab and the possibility of their joint administration.

Check result:

Dimetapp, Childrens Non-Drowsy Allergy ODT <> PCE Dispertab

Relevance: 16.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Macrolide antibiotics may increase the plasma concentrations of loratadine through inhibition of CYP450 3A4 or 2D6 enzymes. Loratadine levels may increase by 40% when coadministered with erythromycin. Clinical monitoring of patient response and tolerance is recommended when macrolides are administered with non-sedating antihistamines. Azithromycin and dirithromycin are not expected to affect loratadine levels and may be considered as alternatives.

References

"Product Information. Claritin (loratadine)." Schering Laboratories, Kenilworth, NJ.
Nahata M "Drug interactions with azithromycin and the macrolides: an overview." J Antimicrob Chemother 37 ( Suppl (1996): 133-42
Ament PW, Paterson A "Drug interactions with the nonsedating antihistamines." Am Fam Physician 56 (1997): 223

Dimetapp, Childrens Non-Drowsy Allergy ODT

Generic Name: loratadine

Brand name: Alavert, Claritin, Claritin Reditab, Clear-Atadine, Dimetapp ND, Ohm Allergy Relief, QlearQuil All Day & Night, Tavist ND, Wal-itin

Synonyms: Dimetapp ND

What is Dimetapp, Childrens Non-Drowsy Allergy ODT?

PCE Dispertab

Generic Name: erythromycin

Brand name: EES. Granules, EES-400 Filmtab, EryPed 200, EryPed 400, Ery-Tab, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, PCE Dispertab, E. E. S, EryPed, Erythrocin, Erythromycin Filmtabs, Erythromycin Lactobionate - IV

Synonyms: PCE Dispertab (Oral), PCE, PCE (Oral)

What is PCE Dispertab?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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