Dimetapp ND and Ketoconazole (Systemic)
Determining the interaction of Dimetapp ND and Ketoconazole (Systemic) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Ketoconazole has been reported to inhibit the metabolism of loratadine. Area under the plasma concentration time curve (AUC) has increased 180% for loratadine and 56% for its active metabolite. The mechanism of this interaction is inhibition of CYP450 3A4 metabolism by ketoconazole. No adverse effects or cardiotoxicity were observed in this study. Loratadine and cetirizine appear to be safe for use with ketoconazole. Terfenadine and astemizole should not be used with ketoconazole.
- Woosley R, Carrow WR "Analysis of potential adverse drug reactions--a case of mistaken identity." Am J Cardiol 74 (1994): 208-9
- "Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ.
- Yumibe N, Huie K, Chen KJ, Clement RP, Cayen MN "Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine." Int Arch Allery Immunol 207 (1995): 420
- "Product Information. Claritin (loratadine)." Schering Laboratories, Kenilworth, NJ.
Generic Name: loratadine
Brand name: Alavert, Claritin, Claritin Reditab, Clear-Atadine, Dimetapp ND, Ohm Allergy Relief, QlearQuil All Day & Night, Tavist ND, Wal-itin
Synonyms: Dimetapp, Childrens Non-Drowsy Allergy ODT
Generic Name: ketoconazole
Brand name: Nizoral
Synonyms: Ketoconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dimetapp ND-Ketoconazole and Hydrocortisone
- Dimetapp ND-Ketoconazole Tablets
- Dimetapp ND-Ketoprofen
- Dimetapp ND-Ketoprofen Capsules
- Dimetapp ND-Ketoprofen Extended-Release Capsules
- Dimetapp ND-Ketorolac
- Ketoconazole (Systemic)-Dimetapp Nighttime Cold & Congestion
- Ketoconazole (Systemic)-Dimetapp, Childrens Non-Drowsy Allergy ODT
- Ketoconazole (Systemic)-Dimethyl fumarate
- Ketoconazole (Systemic)-Dimethyl sulfoxide
- Ketoconazole (Systemic)-Dimethyl sulfoxide Intravesical
- Ketoconazole (Systemic)-Dino-Life