Dimethyl sulfoxide Intravesical and Protriptyline Hydrochloride

• Generic Name: dimethyl sulfoxide
• Dosage Forms: n.a.
• Other Brand Names: Cryoserv, Rimso-50

Dimethyl sulfoxide is a purified preparation used in the bladder to relieve the symptoms of the bladder condition called interstitial cystitis. A catheter (tube) or syringe is used to put the solution into the bladder where it is allowed to remain for about 15 minutes. Then, the solution is expelled by urinating.

Interstitial cystitis is the only human use for dimethyl sulfoxide that is approved by the U.S. Food and Drug Administration (FDA).

Claims that dimethyl sulfoxide is effective for treating various types of arthritis, ulcers in scleroderma, muscle sprains and strains, bruises, infections of the skin, burns, wounds, and mental conditions have not been proven.

Although other preparations of dimethyl sulfoxide are available for industrial and veterinary (animal) use, they must not be used by humans, because of their unknown purity. Impurities in these preparations may cause serious unwanted effects in humans. Even if dimethyl sulfoxide is applied to the skin, it is absorbed into the body through the skin and mucous membranes.

Dimethyl sulfoxide is available only with your doctor's prescription.

• Generic Name: protriptyline
• Dosage Forms: n.a.
• Other Brand Names: Vivactil

Treatment of depression.

Because of its activating properties, particularly suitable for withdrawn and anergic patients.

Has been used for the symptomatic management of OSAHS; however, has not been shown to reduce the frequency of apnea and may cause bothersome anticholinergic effects. Standard treatment(s) for underlying obstruction (e.g., continuous positive airway pressure) and use of adjunctive pharmacologic agents to relieve excessive daytime sleepiness (e.g., modafinil) currently are preferred in patients with this condition.