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Dinoprostone Vaginal Suppositories and Methergine

Determining the interaction of Dinoprostone Vaginal Suppositories and Methergine and the possibility of their joint administration.

Check result:
Dinoprostone Vaginal Suppositories <> Methergine
Relevance: 27.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using dinoprostone topical and methylergonovine is not recommended. Taking these drugs together can cause symptoms of severe cramping or bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: The use of other oxytocic agents with dinoprostone may stimulate uterine hypertonus, which can lead to uterine rupture or cervical laceration, particularly in the presence of an undilated or poorly dilated cervix.

MANAGEMENT: The concomitant use of dinoprostone with other oxytocic agents is considered contraindicated.

References
  • "Product Information. Prostin E2 Suppository (dinoprostone topical)." Pharmacia and Upjohn, Kalamazoo, MI.
  • "Product Information. Prostin E2 (dinoprostone topical)." Pharmacia and Upjohn, Kalamazoo, MI.
Dinoprostone Vaginal Suppositories

Generic Name: dinoprostone topical

Brand name: Cervidil, Prepidil, Prostin E2

Synonyms: Dinoprostone topical, Dinoprostone

Methergine

Generic Name: methylergonovine

Brand name: Methergine

Synonyms: Methergine (oral and injection)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle