Diovan Tablets and Elexacaftor, Tezacaftor and Ivacaftor

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with elexacaftor may increase the plasma concentrations of drugs that are substrates of the organic anion transporting polypeptide protein (OATP) 1B1 and 1B3 transporters. The proposed mechanism, based on in vitro data, involves decreased metabolic clearance due to inhibition of OATP 1B1- and 1B3-mediated hepatic uptake by elexacaftor and its metabolite. The clinical relevance is unknown. MANAGEMENT: Caution is advised when elexacaftor is used concurrently with drugs that are known OATP 1B1 and 1B3 substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever elexacaftor is added to or withdrawn from therapy. References "Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.

MONITOR: Coadministration with elexacaftor may increase the plasma concentrations of drugs that are substrates of the organic anion transporting polypeptide protein (OATP) 1B1 and 1B3 transporters. The proposed mechanism, based on in vitro data, involves decreased metabolic clearance due to inhibition of OATP 1B1- and 1B3-mediated hepatic uptake by elexacaftor and its metabolite. The clinical relevance is unknown.

MANAGEMENT: Caution is advised when elexacaftor is used concurrently with drugs that are known OATP 1B1 and 1B3 substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever elexacaftor is added to or withdrawn from therapy.

Diovan Tablets

Generic Name: valsartan

Brand name: Diovan

Synonyms: Diovan

What is Diovan Tablets?

Elexacaftor, Tezacaftor and Ivacaftor

Generic Name: elexacaftor / ivacaftor / tezacaftor

Brand name:

Synonyms: n.a.

What is Elexacaftor, Tezacaftor and Ivacaftor?